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Medical Weight Loss in Philadelphia

Physician-Guided, Personalized Weight Loss at Enigma Medi Spa

If you’re frustrated with temporary diets and inconsistent progress, discover a medically supervised, results-driven weight loss program trusted across Philadelphia. Enigma Medi Spa offers a comprehensive, physician-directed approach featuring FDA-approved medications, clinical monitoring, and integration with advanced body contouring treatments.

Medical Weight Loss in Philadelphia

Physician-Guided, Personalized Weight Loss at Enigma Medi Spa

If you’re frustrated with temporary diets and inconsistent progress, discover a medically supervised, results-driven weight loss program trusted across Philadelphia. Enigma Medi Spa offers a comprehensive, physician-directed approach featuring FDA-approved medications, clinical monitoring, and integration with advanced body contouring treatments.

Why Choose Enigma Medi Spa for Medical Weight Loss?

Northeast Philadelphia (Enigma Medi Spa & Laser Center)

Supervised by Dr. Nicolaus Mephis, MD.

Phone: 215-717-7000

Rittenhouse / Center City (Enigma Medi Spa & Plastic Surgery)

Supervised by Dr. Elie Goldenberg, MD.

Phone: 215-717-7117

Both locations offer flexible scheduling, advanced medical equipment, and supportive, personalized care.

What Makes Our Program Different?

Board-Certified Medical Oversight

Treatment plans are designed and monitored by our physicians, ensuring safe dosing, clear expectations, and individualized guidance.

Advanced, FDA-Approved Medications

We offer:

  • Semaglutide (GLP-1 therapy; active ingredient in Wegovy®)
  • Tirzepatide (dual GLP-1/GIP therapy; active ingredient in Zepbound®)
These medications help regulate appetite, support metabolic health, and promote steady weight loss.

Integrated Aesthetic Enhancement Options

For clients wanting full-body transformation, weight loss can be combined with:

Consistent Check-ins & Lifestyle Support

Your physician and medical team track your progress, adjust dosing, and provide simple, realistic lifestyle recommendations.

Medical Weight Loss Treatments at Enigma Medi Spa

Semaglutide Injections (GLP-1 Therapy)

How Semaglutide Works

Semaglutide reduces cravings, regulates blood sugar, and promotes steady fat loss. Many patients lose 10–15% of their body weight within the first year.*

Tirzepatide Injections (Dual GLP-1/GIP Therapy)

Why Tirzepatide Provides Enhanced Results

Tirzepatide delivers deeper appetite control, improved metabolic response, and some of the most significant clinical weight loss results—up to 20% body weight reduction*.

*Individual results vary. Physician assessment required.

Enhance Your Transformation With Body Contouring

Medical Weight Loss + Sculpting = Maximum Results

CoolSculpting®

Freeze stubborn fat pockets for long-lasting contouring.

CoolTone®

Strengthen and tone muscles using magnetic stimulation.

SculpSure®

Laser heat melts fat while keeping treatments comfortable and precise. Whether you want fat reduction, definition, or muscle tone, our team can build a combined plan tailored to your goals.

How the Program Works

Your Step-by-Step Transformation

1. Consultation With Your Physician

Meet with Dr. Mephis (Northeast) or Dr. Goldenberg (Rittenhouse) to review your medical history and weight loss goals.

2. Personalized Treatment Plan

Your provider prescribes Semaglutide or Tirzepatide and outlines a simple weekly routine, plus optional contouring add-ons.

3. Monthly Follow-Ups

We check progress, adjust your dosage, and ensure you feel supported throughout your journey.

4. Body Sculpting Integration

As the weight comes off, sculpting treatments help sharpen your results and boost confidence.

Most clients feel appetite changes within the first week.

Success Stories From Philadelphia Patients

Real patient transformation (Before & After).

“Semaglutide plus CoolSculpting changed my life. I’m down 25 pounds and feel incredible!”

— Jennifer L., Philadelphia

“Tirzepatide gave me results I never thought possible. CoolTone helped me see definition for the first time in years.”

— David R., Northeast Philadelphia

Medical Weight Loss Success Stories

Real Medical Weight Loss success stories from Enigma Medi Spa patients in Philadelphia.

Melissa S.

Lost 32 lbs with Tirzepatide + CoolSculpting®

The difference in my confidence is unbelievable. Tirzepatide helped me lose weight at a pace that worked for my lifestyle, and CoolSculpting shaped my stomach perfectly. Dr. Goldenberg and the Rittenhouse team guided me every step of the way.

Kevin D.

Northeast Philadelphia · Stronger Core

Semaglutide finally gave me control over my appetite. Once the weight started coming off, I added CoolTone. My core is the strongest it has ever been. The Northeast Enigma team made the entire journey enjoyable.

Ana R.

Steady Fat Loss While Traveling

I’m constantly on the road for work, but Tirzepatide fit into my schedule. I lost 28 pounds without feeling overwhelmed. CoolSculpting on my back and arms added the definition I always wanted.

Marina K.

Sculpted, Smooth Waistline + 24 lbs Lost

Dr. Goldenberg customized my plan and adjusted it as needed. The combination of Semaglutide and SculpSure made my results look toned and natural. I feel younger and more energetic.

Daniel P.

40 lbs Down + Muscle Definition

I tried everything before coming to Enigma. Tirzepatide was the first thing that truly worked. CoolTone helped me shape my legs and glutes so everything looked athletic.

Erika T.

Bridal Transformation – 22 lbs Lost

I wanted to feel confident for my wedding photos — and I absolutely do. The Enigma team recommended Semaglutide with a few CoolSculpting sessions. My waistline has never looked better.

Lily M.

18 lbs Lost + Smoother Midsection

I appreciated the personal attention from Dr. Goldenberg. He adjusted my dosage and made sure I stayed on track. SculpSure added the perfect finishing touch to my results.

Jacob F.

Athletic Build + Renewed Confidence

Semaglutide helped control my appetite; CoolTone helped define my muscles. I feel strong, healthy, and confident again.

Tasha W.

35 lbs Lost + Arm Contouring

I was nervous to start, but the staff at Enigma made me feel safe. Tirzepatide helped me lose 35 pounds, and CoolSculpting gave my arms shape I’ve never had before.

The difference in my confidence is unbelievable. Tirzepatide helped me lose weight at a pace that worked for my lifestyle, and CoolSculpting shaped my stomach perfectly. Dr. Goldenberg and the Rittenhouse team guided me every step of the way.

Melissa S.

Lost 32 lbs with Tirzepatide + CoolSculpting®

Rittenhouse

Semaglutide finally gave me control over my appetite. Once the weight started coming off, I added CoolTone. My core is the strongest it has ever been. The Northeast Enigma team made the entire journey enjoyable.

Kevin D.

Stronger Core + 27 lbs Down

Northeast Philadelphia

I’m constantly on the road for work, but Tirzepatide fit into my schedule. I lost 28 pounds without feeling overwhelmed. CoolSculpting on my back and arms added the definition I always wanted.

Ana R.

Steady Fat Loss While Traveling

Philadelphia

Dr. Goldenberg customized my plan and adjusted it as needed. The combination of Semaglutide and SculpSure made my results look toned and natural. I feel younger and more energetic.

Marina K.

Sculpted, Smooth Waistline + 24 lbs Lost

Rittenhouse

I tried everything before coming to Enigma. Tirzepatide was the first thing that truly worked. CoolTone helped me shape my legs and glutes so everything looked athletic.

Daniel P.

40 lbs Down + Muscle Definition

Northeast

I wanted to feel confident for my wedding photos — and I absolutely do. The Enigma team recommended Semaglutide with a few CoolSculpting sessions. My waistline has never looked better.

Erika T.

Bridal Transformation – 22 lbs Lost

Center City

I appreciated the personal attention from Dr. Goldenberg. He adjusted my dosage and made sure I stayed on track. SculpSure added the perfect finishing touch to my results.

Lily M.

18 lbs Lost + Smoother Midsection

Rittenhouse

Semaglutide helped control my appetite; CoolTone helped define my muscles. I feel strong, healthy, and confident again.

Jacob F.

Athletic Build + Renewed Confidence

Northeast

I was nervous to start, but the staff at Enigma made me feel safe. Tirzepatide helped me lose 35 pounds, and CoolSculpting gave my arms shape I’ve never had before.

Tasha W.

35 lbs Lost + Arm Contouring

Philadelphia

Body Contouring Success Stories

Christina M.

Hourglass Waist with CoolSculpting®

I had stubborn fat around my midsection that no workout touched. CoolSculpting finally gave me the waistline I wanted. My clothes fit completely differently — in the best way.

Jason R.

CoolTone® Abs for the First Time Ever

I wasn’t overweight, but I could never get abdominal definition. After 6 CoolTone sessions, my abs became visible. I still can’t believe the difference.

Sonia P.

SculpSure® Thighs + Smooth Contours

SculpSure treated areas I could never fix on my own. My legs are smoother, and the shape is noticeably more feminine.

I had stubborn fat around my midsection that no workout touched.
CoolSculpting finally gave me the waistline I wanted. My clothes
fit completely differently — in the best way.

Christina M.

Hourglass Waist with CoolSculpting®

I wasn’t overweight, but I could never get abdominal definition.
After 6 CoolTone sessions, my abs became visible. I still can’t
believe the difference.

Jason R.

CoolTone® Abs for the First Time Ever

SculpSure treated areas I could never fix on my own. My legs are
smoother, and the shape is noticeably more feminine.

Sonia P.

SculpSure® Thighs + Smooth Contours

Combination Treatment Stories

Natalia R.

Weight Loss + Body Sculpting Package

I did Semaglutide along with CoolSculpting and CoolTone. The combination made me look and feel transformed from every angle.

Michael H.

Complete Midsection Makeover

CoolSculpting reduced the fat, CoolTone built the muscle, and Semaglutide helped me maintain the weight loss. Enigma changed how I feel in my clothes.

I did Semaglutide along with CoolSculpting and CoolTone. The combination made me look and feel transformed from every angle.

Natalia R.

Weight Loss + Body Sculpting Package

CoolSculpting reduced the fat, CoolTone built the muscle, and Semaglutide helped me maintain the weight loss. Enigma changed how I feel in my clothes.

Michael H.

Complete Midsection Makeover

Medical Disclaimer

Important Information

All treatments require physician evaluation. Semaglutide and Tirzepatide are prescription medications and are provided only when medically appropriate. Individual results vary.

Medical Weight Loss – FAQ

1. Who is a good candidate for medical weight loss at Enigma Medi Spa?

Adults who struggle to achieve weight loss through diet and exercise alone may be good candidates. Eligibility depends on your medical history, BMI, and overall health. A consultation with our medical provider is required to determine if Semaglutide or Tirzepatide is appropriate for you.

2. How quickly will I see results with Semaglutide or Tirzepatide?

Many clients experience appetite changes within the first week. Steady weight loss typically begins within the first few weeks and continues over several months. Your exact timeline depends on your dosage, metabolism, and lifestyle.

3. How do Semaglutide and Tirzepatide work?

Semaglutide is a GLP-1 medication that helps regulate appetite, control cravings, balance blood sugar, and support gradual fat loss.

Tirzepatide is a dual GLP-1/GIP medication that boosts fullness, improves metabolic function, and delivers faster, more powerful weight-loss results.

Both are FDA-approved prescription therapies.

4. Are Semaglutide and Tirzepatide safe?

Yes, both medications are FDA-approved and widely studied for safety and effectiveness. However, as with any prescription therapy, they may cause side effects such as nausea, mild stomach discomfort, or fatigue. Our medical provider carefully reviews your health history and monitors your progress throughout treatment.

5. What side effects should I be aware of?

Possible side effects include nausea, digestive upset, constipation, diarrhea, and decreased appetite. These symptoms usually lessen as your body adjusts. Your provider will discuss all potential risks and how to minimize them.

6. Do I need to follow a diet or exercise plan?

Yes—while the medication helps regulate appetite, long-lasting results come from balanced eating and regular activity. Our team provides simple, realistic guidance tailored to your lifestyle. No extreme diets or difficult plans are required.

7. How often are injections given?

Treatments are typically administered once a week, with dosage adjustments based on your progress and tolerance.

8. How long will I need to stay on the medication?

Treatment duration varies. Some clients stay on the medication for a few months, while others continue longer for sustained results. Your provider will evaluate your progress and recommend a plan that aligns with your goals.

9. Can I combine medical weight loss with body contouring treatments?

Absolutely. Many clients choose to pair weight loss injections with body sculpting for enhanced results. Popular combination treatments include:

This combined approach helps you lose weight while refining your overall shape.

10. Are results permanent?

Weight loss can be long-lasting with proper lifestyle habits. Continuing healthy nutrition, physical activity, and follow-up support will help maintain your results. Body contouring results are typically permanent because fat cells destroyed through treatments do not return.

11. Is the consultation really free?

Yes. New medical weight loss clients receive a complimentary consultation with our medical provider to review goals, evaluate candidacy, and build a personalized plan. You also receive 10% off your first injection series if you choose to start.

12. What is the cost of the program?

Pricing depends on the medication, dosage, and add-on treatments such as body contouring. All costs are discussed clearly at your consultation with no surprise fees.

13. Can I start treatment during my consultation?

In many cases, yes—if you are medically approved and labs or additional evaluations are not required, treatment can begin the same day.

14. Do you offer financing?

Yes. We accept Cherry, CareCredit, credit cards, and Apple Pay. Our team can help you explore flexible payment options during your visit.

Start Your Transformation Today

Free Consultation + 10% Off Your First Injection Series Take the first step toward a healthier, more confident you. Thousands of clients across Philadelphia choose Enigma because we deliver results safely, compassionately, and consistently.
  • Free medical weight loss consultation
  • Personalized plan with Dr. Nicolaus Mephis or Dr. Elie Goldenberg
  • Multi-modality options (Semaglutide, Tirzepatide, CoolSculpting, CoolTone, SculpSure)
  • Two convenient locations: Northeast Philadelphia & Rittenhouse

Northeast: (215) 717-7000
Rittenhouse: (215) 717-7117

What People Say About Us

Backed by Proven, Consistent Results

Everyone is so nice here! They always treat you with kindness and explain everything in detail. My face feels so nice after my treatment!

5/5

Emily

Everyone was friendly. Olga provided treatment service and did great at explaining. I highly recommend Enigma.

5/5

Trinity

Syreeta was very sweet and made me feel very comfortable.I was very happy with my results!

5/5

Lauren

Everyone is so nice here! They always treat you with kindness and explain everything in detail. My face feels so nice after my treatment!

Emily

Everyone was friendly. Olga provided treatment service and did great at explaining. I highly recommend Enigma.

Trinity

Syreeta was very sweet and made me feel very comfortable.I was very happy with my results!

Lauren

Awards

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